Too much methylfolate reddit. This is why there has been no upper limit set for b12.
● Too much methylfolate reddit For me taking Deplin (which is also 15mg methyl folate) for weeks didn't seem to have a positive or negative effect. I was prescribed 15mg for depression, but it makes me very very anxious and I don't want to use methylfolate as a treatment for depression necessarily, just for the MTHFR illness. I have other confounding factors like dysfunctional childhood and cocaine addiction but I believe MTHFR is the primary reason I had ADHD. My mental health has been in a terrible state for a while, maybe longer than i’ve been on this, but is it possible I could have overmethylated? Too much puts you into overmethylation. Here's the thing: the two mutations commonly tested for are only 2 of something like 40 genes suspected to be involved in methylation so they're a horrifically incomplete picture of what may be going on. A genesite test showed I had one inactive allele that would code for producing L-methylfolate from folate or folic acid. g. I do have riboflavin deficiency but cant solve it due to hyporhyroid and the most obvious two symptom is too much serotonin and reduced light sensing. Heart beating, tightness of chest etc. If that's the one thing you're missing, yeah, it might make you feel better. It causes fatigue during the day, insomnia, and makes me have pain during a Bowel Movement, and then forces m to take a nap after BM for 1. A few days afterwards, I reduced my Methylfolate to 400mcg, and that has been working much better - still having the mental clarity/lucidity without the brain fog. The dose of methylfolate is selected individually by gradually increasing the dosage, no one knows how much you personally may need. Odd mood reaction to too much methylfolate, has anyone had this and can explain it? Background: I am heterozygous C677T and A1298C, have a few other heterozygous mutations (DHFR, MTR, MTRR), homozygous mutations in 2 COMT genes, have obstructive sleep apnea, ADHD, and have been struggling with depression and anxiety. Now Im trying to increase the dosage slowly and have been having good results. I got genetic testing done, found out I have a folate deficiency and an inability to process folic acid, began supplementing with NAC used to clear my fog, but now methylfolate seems to do the same and make NAC do pretty much nothing, so I suspect I really do have low methylation capacity at least as one of my problems, since low methylation would also probably Ever since initiating the methylfolate, I've had a major, life changing difference with my mental health and just how I think, regulate mood, my self talk, etc. I switched prenatals to get rid of folic acid and have now been taking Best Nest Wellness Mama Bird with 800mcg methylfolate + folinic acid. I have an appointment with an Integrative Medicine specialist in May, but it would be nice to find a supplement before then! Just from the 200 micrograms in a multivitamin. If you added-on more in supplement form, then added 5-MTHF in addition I would expect that to have a negative effect. i see lots of people say they are sensitive to methylfolate and replace it with folinic acid, but methylcobalamin doesn't seem to be mentioned as much in such contexts. Or check it out in the app stores It’s as if the body must utilize all of it at once because it is in active form pushing the body to try to do too much at once. Or check it out in the app stores That's way too much. It's nearly impossible to overdose as it is water soluble. I was using 15mcg of the MTHFR, per my MD's orders, and it was too much. My serum folate is 5. or any folate other than in meals. im gonna try 50 mg nicotinic acid as a fix because im sensitive to methyl donnors cause of ComT, so that might be the issue. Remember, too, that just because you have a mutation doesn't mean it's active. ) It’s best to get in diet only but you can check levels Overmethylation may be linked to intaking too many methyl donors (i. I feel lucky I actually know about these effects of methylfolate. ) Heard about methyl folate and decided to try it out since it wasn’t too expensive online (Now brand, Amazon). However, I still feel some of the side effects of the 800mcg at a lower intensity (like dizziness, minor akathisia), so I think I will even try decreasing to 200mcg for a while. AIP tends toward deficiency in calcium, magnesium, manganese, molybdenum, lithium, and silicon. 3 ng/ml. But a lot of people start taking methylfolate only to run out of some other cofactor, like other B vitamins, magnesium, zinc, etc. I’ll try not to get into a big rant here on that and get to the point. I didnt exceed 400mg dosage and day by day symptoms got worse till worst mast cell flare up showed up. You mention being vegetarian. Sometimes it feels like I'm taking too much- I can't explain why, it's just an off feeling. 5 microg/L on a lab normal range of 3-20 so I think that's low especially since I've just discovered I can't turn much of it into methylfolate! B12 was 541 ng/L on a normal lab range of 180-900 so not too bad. For example, according to the International Journal of Cancer, 35% of the Can easily become negative if I take too much, especially with creatine Creatine ~4 g daily, 1 g at a time Speeds up my thinking and gives me mental energy an resilience Gives me physical endurance Used to take less, but 4 g helps keep my levels up better and I can tolerate if if I don't take 5-MTHF too much Yes, it is possible. And the whole energy metabolism and krebs cycle is so complex, u can't just optimize everyone who has an MTHFR SNP with B9. Reddit: a social network where you can find people who agrees with you and your theories Methylfolate, at lower doses, is the better supplement to take. After supplements Methylcobalamin and Methylfolate I started to urinate too much. can it also induce overmethylation? should one avoid taking both at the same time, or avoid taking too much methylcobalamin? I'm surprised then you don't mention a methyl B12, given mega dose would exacerbate such issues too. 5 nd it's still too much. TW: Miscarriage I am jumping on this thread because I’m also heterozygous for A1298C and learned this less than a month ago. too much Methylfolate cured my depression and is helping me handle chronic fatigue, but Im still figuring out the dosage. Then you would have produced melatonin during the day, when it's usually produced much more at night Get the Reddit app Scan this QR code to download the app now. Thank you for your answer mate. I was recommended to start taking 15mg of l-methylfolate a day. I do, but so has half the population, and they are different. This makes SO MUCH SENSE. I am now 7. Iron utilization. ” A nontrivial percentage of the population cannot convert adequate amounts of folate, an important B vitamin, to methylfolate, often due to MTHFR gene variants, and other SNPs that affect the methylation cycle. I'm on a pretty high dose (15) of l-methylfolate. So I was on 5mg daily for 1 month & have not been taking any for a week. General Discussion I (M38) started supplementing Methylcobalamin 1000mcg and methyl folate 1000mcg daily due to B12 deficiency, right after I started I noticed that I urinated too much not like normal, and the amount of urine also is much higher than normal. And as a result, I feel like I've actually seen the effects of this. In medical literature, however, demyelination and other B12 deficiency symptoms have been recorded as people with borderline B12 status who corrected their folate deficiencies found that their low B12 stores were rapidly used. Internet Culture (Viral) it is best to start low and go slow with both L-Methylfolate and Vitamin B12 because too much of a good thing added too quickly can potentially lead to some unwanted emotional changes that could be I am going to keep saying this over and over on this forum because it seriously was a game changer for me. Generally though Methylfolate is used in the methylation cycle but too much shuts that down. By supplementing for them instead of folate, I realized that I don’t need that much folate. I've also been prone, my entire life, to anxiety and depression (also have ADHD and take Ritalin [Methylphenidate for it) - started taking Escitalopram (Cipralex/Lexapro) but didn't notice much benefit from it even after 3 months. 1. Yet as far as focusing on tasks or bettering myself has been, not much has changed. . So many people have the mthfr mutation, but other factors can reduce our natural ability to convert folic acid to l-methylfolate. Whenever people doubt the validity of methylfolate I like to point out that you can get it prescribed under the Get the Reddit app Scan this QR code to download the app now. i have the exact same mutations as you and i respond to methylfolate the exact same way too. but i need it regardless of anxiety otherwise fatigue digestive issues allergies and brain fog eat me alive. methylfolate) & can lead to poor concentration, anxiety, panic attacks, & sensitivities to environmental toxins, among other symptoms. I realised on April 11th so stopped taking methylfolate. Methylfolate and Methyl-B12, combined, almost entirely suppress my chronic allergies, better than any antihistamine. In my opinion, Any amount of folic acid is way too much if you have access to L-5-Methyltetrahydrofolate especially if you have a MTHFR mutation. He's now running more tests. One mistake I made with AIP was not getting enough calcium and magnesium which caused poor sleep. TMG, for me, is easier to dose and includes glycine, which is a plus, and once it loses two methyl groups becomes sarcosine (I believe). I have tons more energy and focus, and feel much better overall. Using methylfolate if you are overmethylated (produce too much SAM-e) and thus too much serotonin will have a diametrically different effect than for undermethylators. At first I didn't feel any changes, so I kept taking it. View community ranking In the Top 10% of largest communities on Reddit. L-methylfolate allows us to synthesize neurotransmitters. Before Methylfolate, i was coping with my symptoms using supplements and diet, including 10 eggs a day, creatine, non methylated b complex, and much more, everything was absolutely perfect UNTIL The day i tried methylfolate, One SINGLE dose of I'd lose the mixed one and just take the individual methylfolate and B12 so you can dial it in. Folate or folic acid appears to turn this gene on. L-methylfolate too much . Or check it out in the app stores TOPICS. (and turns off other methyltransferases). Long story short, too much folate is not good for us. WOWnight and day difference compared to where I was before. You are supposed to avoid all folic acid on methylfolate, by the way, as it blocks uptake. If not eaten from natural sources, the methyl folate can be taken to supplement the slower reactions. Tons of vegetarian stuff is supplemented with folic acid. You could be low, get a lot of iron, and your body will be upset from too much incoming iron and it not being able to properly move it, with things like hepcidin In clinical trials of Deplin, which is prescription methylfolate, there were no significant side effects recorded. You're psyching yourself up. Recently learned I have a mutated MTHFR gene and for starters WOW. E. I didn't want to take the prescription folic acid (5 grams) because it felt like too much, so I took 800 mcg for 2-3 months. Even 100mcg is sufficient. 400 mcg methylfolate 500 mcg methylcobalamin I used to take 1,600 mcg methylfolate but found 400 mcg is just as effective. This is why there has been no upper limit set for b12. Then yesterday I heard a JRE podcast about how the US sprays everything with Folic Acid unless it's organic and supposedly 40+% of people can't process it and it's poisoning them. Whenever I take higher doses of methylfolate/B12 I feel overmethylated and either feel down or anxious, but TMG and NAC do not seem to have the same effect (at least not as much). I had pretty bad effects with 800mcg methylfolate. Methylfolate is supposed to have better bioavailability but if no one works for you give a try to the Trimethylglycine (TMG Betaine) which is able to re-methylate homocysteine (assuming you are looking for that). EDITED: Having too much dopamine — or too much dopamine concentrated in some parts of the brain and not enough in other parts — is linked to being more competitive, aggressive and having poor impulse control. My BP seems to be unaffected by this new supplement (consistently 117/77) so I’m keen to keep taking them. Hey guys, So I took 400mcg of Methylfolate and been experiencing some intense anxiety now a few hours after. My doctor is great but I'm not sure she knows a Ken, it’s because neurotransmitters require folate to function. MTHFR mutations usually pull the balance towards Methylfolate supplements can come with side effects, even if you “have MTHFR. I'm a 27-year-old girl, earlier this year I did a blood test and saw I have relatively low folic acid - 3. I've heard that very large (>1mg) amounts of methylfolate can negatively affect people, maybe particularly if they're homozygous MTHFR. L-5-MTHF (L-methylfolate) B12 (cobalamin) Methionine Homocysteine Folic acid Here is the goal: We want healthy serum levels of L-methylfolate, B12 and methionine (not too much, not too little) We want as little serum homocysteine as possible (it If you have low folate, it's likely that you will experience good results from choline - one of the functions of folate is that it helps recycle homocysteine into much needed metabolites, choline is another pathway that does the same job, so if low on folate, the choline pathway may have been relied on for too long. He had me on 15mg a day and my anxiety increased 5 fold and I started having severe panic attacks thinking it was my Delta-8 THC. e. If you have too little, serotonin will be too high. B6, glucosamine and riboflavin should be unnecessary if you have a balanced diet. I My psychiatrist prescribed me L-methylfolate to help my anti depression meds do their job. One week was fine, then symptoms of methylfolate side effects occurred. I've seen on this site that some doctors are prescribing niacin to slow the overmethylation, but don't know what dose or how often. I'm homozygous for C677T and wanted to know how much should I take to satisfy my body needs. Instead, consider the added choline from the protocol, which makes use of the alternate remethylation pathway in the methionine cycle One gene methyl turns off is the serotonin reuptake gene. And often people with MTHFR are low on other cofactors too. I was thinking I should catch up on lost B9. Chris Masterjohn recommends choline as an alternative methyl donor for that Never worry about too much b12. If someone can’t process much folic acid, they need other forms of folate. I’ve been taking l-methylfolate for about 3 years at 15mg because I was told I have the MTHFR gene. Most people consume too much folate (regardless of methylation status. Get the Reddit app Scan this QR code to download the app now. It can lead to conditions that include ADHD, binge eating, addiction and Most people already get waaaay too much folic acid in their diet. Or check it out in the app stores Can I go from undermethylation to overmethylation with too much methylb12 and methylfolate? Question I learned about methylation a few years back, took the 23andme test like many of you, discussed the results with my doctor, and began I am getting much better and controllable improvements if I focus on downstream systems that rely on folate like the choline and creatine synthesis ones. B12 uses up Too much can result in overmethylation symptoms. The body prioritizes them in different manners and sometimes will methyl the vitamins (if unmethylated) for other functions. In general, minerals are tricky because there is no substitutes for them and one has to get the right amount (not too much and not too little). You will likely be low in potassium making you feel on edge. If not, I can take up to 15mg as well. My psychiatrist gave me 2 weeks of Deplin samples. (Since it made no difference in that regard, even after four months). Supplementation of B12 for a number of weeks prior to supplementing methylfolate, will It depends if you have symptoms with it. 5 mg is a lot for the average person, although for some types of depression that are resistant to antidepressant treatment, up to 16 mg of methylfolate is prescribed or more. I wouldn't trust the test so much, they are too unspecific. Try 400ug. I asked how long it will take to drop my level back to normal but he had no answer. Reduced it to 400mcg and felt much better after a couple of days. Too much B6 is bad especially - I wouldn't supplement any if I were you. Even 100 mcg is too much! Yeah, I could take only methylfolate, but my research indicates it needs to be balanced with other B vitamins. This can cause “methyl trapping”, where the excess methylfolate is unable to be utilised in the methionine cycle (through the MTR enzyme) as usable B12 levels are too low. Early Feb I switched to methylfolate 1mg daily 11th March switched to 5mg methylfolate daily. I can't imagine how many people start a multivitamin with methylfolate in it and after a while develop mental health issues because of it, but aren't able to understand that methylfolate is causing this and they just keep taking it. If you have too much serotonin reuptake happening, serontonin levels will be low. 5 hours. B12 deficiancy is strongly correlated with depression, too. My doctor asked me to stop the supplement asap. “It’s just a supplement, surely it won’t have any side effects/etc” WRONG lol Bought 6 bags of oat cereal (Purely Elizabeth, Organic Ancient Grain Granola) and I've felt fine after consuming way too much. A back-up of NAS could have been taken care of by increased SAM that was produced by the methylfolate. (Yes, you can have too much serotonin in your body and some people do. You could try 1000mcg but I suspect it won't provide any added benefit. dsutqsilwveksriquslsmrnqqadkzruwtcfmlsycmqsasdzosbdqrph